A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds

Jinbing Liu; Rihui Cao; Wei Yi; Chunming Ma; Yiqian Wan; Binhua Zhou; Lin Ma; Huacan Song

doi:10.1016/j.ejmech.2008.04.002

A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds

Eur J Med Chem. 2009 Apr;44(4):1773-8. doi: 10.1016/j.ejmech.2008.04.002. Epub 2008 Apr 27.

Authors

Jinbing Liu¹, Rihui Cao, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song

Affiliation

¹ School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, PR China.

PMID: 18524420
DOI: 10.1016/j.ejmech.2008.04.002

Abstract

A series of alkylidenethiosemicarbazide compounds were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that most of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 1f was found to be the most potent inhibitor with IC(50) value of 0.086 microM, suggesting that further development of such compounds may be of interest.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Agaricales / enzymology
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
Inhibitory Concentration 50
Monophenol Monooxygenase / antagonists & inhibitors*
Semicarbazides / chemical synthesis
Semicarbazides / chemistry*
Semicarbazides / pharmacology*

Substances

Enzyme Inhibitors
Semicarbazides
carbamylhydrazine
Monophenol Monooxygenase